Liverpool headed down south in search of their first win in four, Jurgen Klopp and his side were looking to right their wrongs from mishaps gone by.
Prior to the line-up announcement, there was a sense of dread amongst the Reds supporters as footage and images emerged showing the absence of Brazilian Fabinho.
Those worries were soon a reality as they fielded three changes from the defeat at Old Trafford on Sunday in the FA Cup.
Jurgen Klopp’s side have won their last six meetings against Spurs, a team the German has previously claimed to me a “counter-attacking monster”.
As a result of Fabinho’s absence, Joel Matip and Jordan Henderson were drafted in as yet another centre-back pairing for the Reds.
The two missed their FA Cup exit on Sunday, but Klopp said: “That is our situation. It was nothing really. He just felt something so we had to take him out and now he’s out.
“It wasn’t in a challenge or anything.
“It was not intense or whatever, it’s how things happen.”
Spurs saw Spaniard, Sergio Reguilón, miss out through injury. The hosts lined up as as a 3-4-3 with Heung-min Son, Harry Kane and Steven Bergwijn lead the line.
On the constant misfortune with defensive injuries, Jurgen concluded: “That’s just how it is.”
Thursday night saw sixth vs fifth and the battle of the tacticians continue.
A win for Liverpool could see them jump into fourth.
However, a win for Jose Mourinho’s side would see them leapfrog the Reds and have a one game deficit over the Merseyside club.