Liverpool make one changes from Saturday’s defeat at the King Power Stadium as Thiago comes in for James Milner.
Jordan Henderson will captain the side for the 195th time in his Anfield career, meaning he will be level with Alan Hansen.
Leicester City inflicted a third consecutive defeat for the six-time Champions League winners at the weekend.
Despite Mohamed Salah’s second-half opener, James Maddison restored parity for the hosts as his teasing free-kick flashed across goal into the far before a seven-minute capitulation saw Jamie Vardy and Ashley Barnes pile on the misery.
Liverpool have already had a whole host of injury problems this season with Virgil van Dijk, Joe Gomez and Joel Matip suffering long term injuries.
More recently, Fabinho, Caomihin Kelleher and Ben Davies missed Saturday’s defeat to Leicester City while James Milner limped off in that game inside half an hour.
Those injuries took the Reds to 10 players ruled out through injury as problems continue to hamper the Premier League champions.
Meanwhile, Julian Nagelsmann’s side have injury problems of their own. They are without highly rated January signing Dominik Szoboszlai as well as key figures including Emil Forsberg, Benjamin Henrichs and Konrad Laimer.
Liverpool Starting Line-Up
Liverpool team to face RB Leipzig: Alisson; Alexander-Arnold, Kabak, Henderson, Robertson; Wijnaldum, Thiago, Jones; Salah, Firmino, Mane.
It will be the first time these two sides have met before as Die Roten Bullen become the Reds 133rd European opposition.
Despite being a home match for Red Bull Leipzig, the Germans have been forced to relocate 795km to Puskás Aréna to host the first leg with the Reds.
This has in turn has forced an air of uncertainty surrounding the second leg on March 10 at Anfield as the Leipzig players would have to isolate for 14 days upon returning from Merseyside.
The final of the UEFA Champions League will be held in Istanbul this year, where Liverpool famously beat AC Milan on penalties in 2005.